货品编号： MCE.HY-N0488

品牌： MCE

品名： Vincristine sulfate (Synonyms: Leurocristine sulfate; 22-Oxovincaleukoblastine sulfate)

规格： 10mg

产品描述：

Vincristine inhibits net addition of tubulin dimers at assembly ends of steady-state microtubules with Kof 85 nM.

Vincristine stabilizes the spindle apparatus resulting in failure of the chromosomes to segregate leading to metaphase

arrest and inhibition of mitosis at low concentrations. At higher concentrations, Vincristine may disrupt and induce total

depolymerization of microtubules.Vincristine induces apoptosis in tumor cells and inhibits SH-SY5Y cell proliferation

with IC50of 0.1 μM. Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B,

while decreasing the expression of cyclin D.Vincristine induced neurotoxicity is caused by interference with microtubule

function, which results in blockage of axonal transport and thus in axonal degeneration