货品编号： bioss.bs-9030R 品 牌：bioss 品 名：Rabbit Anti-PAPSS2 an 规 格： 100ul 产品描述： 研究领域 细胞生物免疫学 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Mouse, (predicted: Human,Rat,Dog,Cow,Horse,Rabbit,) 产品应用 WB=1:500-2000ELISA=1:500-1000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 68kDa 细胞定位 细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated synthetic peptide derived from human PAPSS2:351-450/614 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMed PubMed

产品介绍 PAPSS2 is one of the two PAPS synthetases. Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS)

is the sulfate donor cosubstrate for all sulfotransferase (SULT) enzymes. SULTs catalyze the sulfate conjugation

of many endogenous and exogenous compounds, including drugs and other xenobiotics. In humans, PAPS is

synthesized from adenosine 5-prime triphosphate (ATP) and inorganic sulfate by 2 isoforms, PAPSS1 and PAPSS2.

Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetases (PAPS synthetase or PAPSS), also designated

sulfurylase kinase (SK), are important for sulfate assimilation in the sulfur metabolism pathway. PAPPS proteins are

bifunctional enzymes with APS kinase and ATP sulfurylase activity, which mediate two steps in the sulfate activation

pathway. The PAPSS proteins belong to the APS kinase family and to the sulfate adenylyltransferase family of proteins.

In mammals, PAPSS proteins are the sole source of sulfate. During postnatal growth, PAPSS proteins may play a role

in skeletogenesis. Defects in the PAPSS2 gene can cause the Pakistani type of spondyloepimetaphyseal dysplasia

(SEMD), an autosomal recessive form of SEMD characterized by short, bowed limbs, enlarged knee joints and mild

brachydactyly.