货品编号： stemcell.60131FI 品 牌：stemcell 品 名：Anti-Human CD38 Antibody, Clone AT-1,FITC 规 格： 100tests 产品描述：

The AT-1 antibody reacts with CD38, an ~45 kDa type II integral membrane glycoprotein that is part of the ADP-ribosyl cyclase family.

CD38 is widely expressed at variable levels on hematopoietic cells including early B and T cell lineages, activated B and T cells, NK

cells, monocytes, and dendritic cells. It is strongly expressed in plasma cells. CD38 is also expressed in some non-hematopoietic tissues

such as brain, kidney, muscle, and pancreas. CD38 is an ectoenzyme that acts as both an ADP-ribosyl cyclase and ADP-ribose (ADPR)

hydrolase for the synthesis and hydrolysis of cyclic ADPR (cADPR) and NAADP. cADPR acts as a second messenger for intracellular

calcium mobilization to facilitate glucose-induced insulin secretion. It has been shown that the AT-1 antibody mutually competes for binding

with OKT10 and SUN-4B7, and all three clones only bind the native (not reduced) form of CD38.

Subtype: 一抗 Target Antigen: CD38 Alternative Names: ADP-ribosyl cyclase, cADPR, Cyclic ADP-ribose hydrolase, T10 Reactive Species: 人; 食蟹猴; 猕猴 Conjugation: FITC Host Species: 小鼠 Cell Type: B细胞; 浆细胞; 造血干细胞和祖细胞 Application: 细胞分离; 流式细胞术 Area of Interest: 免疫学; 干细胞生物学 Clone: AT-1 Gene ID: 952 Isotype: IgG1, kappa