货品编号：博奥森.bs-3238R

品牌：博奥森

品名：磷酸化蛋白质酪氨酸激酶JAK-1抗体

规格：100ul

产品类型磷酸化抗体

研究领域肿瘤细胞生物免疫学染色质和核信号信号转导细胞凋亡激酶和磷酸酶表观遗传学 抗体来源Rabbit 克隆类型Polyclonal 交叉反应Human,(predicted:Mouse,Rat,Pig,Cow,) 产品应用WB=1:500-2000ELISA=1:5000-10000Flow-Cyt=2μg/Testnotyettestedinotherapplications.optimaldilutions/concentrationsshouldbedeterminedbytheenduser. 分子量133kDa 细胞定位细胞膜 性状Liquid 浓度1mg/ml 免疫原KLHconjugatedSynthesisedphosphopeptidederivedfromhumanJak1aroundthephosphorylationsiteofTyr1034+Tyr1035:KE(p-Y)(p-Y)TV 亚型IgG 纯化方法affinitypurifiedbyProteinA 储存液0.01MTBS(pH7.4)with1%BSA,0.03%Proclin300and50%Glycerol. 保存条件Shippedat4℃.Storeat-20°Cforoneyear.Avoidrepeatedfreeze/thawcycles. PubMedPubMed 产品介绍Januskinase1(JAK1)isamemberofanewclassofnonreceptorproteintyrosinekinases(PTK)characterizedbythe

presenceofasecondphosphotransferaserelateddomainimmediatelyNterminaltothePTKdomain.Thesecond

phosphotransferasedomainbearsallthehallmarksofaproteinkinase,although

itsstructuredifferssignificantlyfromthatofthePTKandthreonine rinekinasefamilymembers.JAK1isalarge,widely

expressedmembraneassociatedphosphoprotein.Itisinvolvedintheinterferonalpha/betaandgammasignaltransduction

pathways.ThereciprocalinterdependencebetweenJAK1andTYK2activitiesintheinterferonalpha

pathway,andbetweenJAK1andJAK2intheinterferongammapathway,mayreflectarequirementforthesekinasesinthe

correctassemblyofinterferonrecpeptorcomplexes.

Thesekinasescouplecytokineligandbindingtotyrosinephosphorylationofvariousknownsignalingproteinsandaunique

familyoftranscriptionfactorstermedthesignaltransducersandactivatorsoftranscription,orSTATs.