货品编号：博奥森.bs-10048R

品牌：博奥森

品名：血管假性血友病因子/血管性血友病因子抗体

规格：100ul

研究领域肿瘤 心血管 细胞生物 发育生物学 生长因子和激素

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, (predicted: Rat, Dog, Cow, Horse, Rabbit, )

产品应用IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量309kDa

细胞定位细胞外基质 分泌型蛋白

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human VWF/Von Willebrand Factor:1651-1800/2813

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen. VWF is synthesized exclusively

by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma.

This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood

coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions

by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor

has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this

gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding

(gingival, minor skin quantitative lacerations, menorrhagia, etc.).