货品编号：Bioss.bs-6741R

品牌：Bioss

品名：Rabbit Anti-ASC antibody

规格：50ul

研究领域肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 肿瘤细胞生物标志物

抗体来源Rabbit

克隆类型Polyclonal

交叉反应Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, )

产品应用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/test IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量22kDa

细胞定位细胞核 细胞浆

性 状Liquid

浓 度1mg/ml

免 疫 原KLH conjugated synthetic peptide derived from human TMS1/ASC:31-130/195

亚 型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

PubMedPubMed

产品介绍Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation

of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8

and CASP1 and whose function would be the activation of proinflammatory caspases. Tissue specificity: Widely

expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at

lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the

leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma.