货品编号： Peprotech.100-20B-500

品 牌： Peprotech

品 名： Human VEGF B

规 格： 500 ug

产品描述：

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial

cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons.

VEGF-B is expressed in all tissues except the liver. It forms cell surface-associated, disulfide-linked homodimers, and can form

heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167

and VEGF-B186. Both forms have identical amino-terminal sequences encoding a cysteine knot-like structural motif, but differ in

their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant Human VEGF-B is

a 38.0 kDa, disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.