货品编号： Biolegend.120414

品 牌： Biolegend

品 名： APC anti-mouse CD105 Antibody

规 格： 100ug

产品描述：

CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial

cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow

stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting

with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been

show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging

and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.