博士德.A01409-1 Anti-TXNIP Antibody 50ul 博士德-耗材-金山科研平台 Thermo Fisher官网Nunc、QSP、Nalgene、Invitrogen、Gibco耗材试剂授权一级代理

博士德.A01409-1 Anti-TXNIP Antibody 50ul 博士德

货品编号：博士德.A01409-1

品牌：博士德

品名： Anti-TXNIP Antibody

规格： 50ul

货号	A01409-1
产品名称	Anti-TXNIP Antibody
基因名	TXNIP
抗体来源	Rabbit
克隆	Polyclonal
抗体亚型	Rabbit IgG
分子量	44KD
免疫原	E.coli-derived human TXNIP recombinant protein (Position: K5-Q391).
内容	500 ug/ml antibody with PBS ，0.02% NaN3 , 1 mg BSA and 50% glycerol.
纯化方式	Immunogen affinity purified.
浓度	500 ug/ml
产品形态	Liquid
保存条件	12 months from date of receipt，-20℃ as supplied. 6 months 2 to 8℃ after reconstitution. Avoid repeated freezing and thawing.
背景资料	Thioredoxin-interacting protein is a protein that in humans is encoded by the TXNIP gene. It is mapped to 1q21.1. This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants.
研究类别	1. Bodnar, J. S., Chatterjee, A., Castellani, L. W., Ross, D. A., Ohmen, J., Cavalcoli, J., Wu, C., Dains, K. M., Catanese, J., Chu, M., Sheth, S. S., Charugundla, K., Demant, P., West, D. B., de Jong, P., Lusis, A. J. Positional cloning of the combined hyperlipidemia gene Hyplip1. Nature Genet. 30: 110-116, 2002.2. Hui, S. T. Y., Andres, A. M., Miller, A. K., Spann, N. J., Potter, D. W., Post, N. M., Chen, A. Z., Sachithanantham, S., Jung, D. Y., Kim, J. K., Davis, R. A. Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc. Nat. Acad. Sci. 105: 3921-3926, 2008.3. Suh, H.-W., Yun, S., Song, H., Jung, H., Park, Y.-J., Kim, T.-D., Yoon, S. R., Choi, I. TXNIP interacts with hEcd to increase p53 stability and activity. Biochem. Biophys. Res. Commun. 438: 264-269, 2013.

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博士德.A01409-1 Anti-TXNIP Antibody 50ul 博士德

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