货品编号： santa.sc-365263

品牌： santa

品名： HAS2抗体

规格： 200ug

HAS1, HAS2 and HAS3 are HA Synthase proteins that synthesize HA (Hyaluronan or hyaluronic acid). The extracellular

matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating

glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds. The three HAS genes show

distinct patterns of expression during development and their protein products play significantly different roles in the formation

of the HA matrix. Both HAS1 and HAS2 synthesise high molecular-weight HA, whereas HAS3 produces lower molecular

weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially

regulated by various stimuli suggesting distinct functional roles of the three proteins. HAS2 mRNA shows predominant expression

in chondrocytes and cartilage. The human HAS2 gene maps to chromosome 8q24.12.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.