货品编号： santa.sc-365263
品牌： santa
品名： HAS2抗体
规格： 200ug
HAS1, HAS2 and HAS3 are HA Synthase proteins that synthesize HA (Hyaluronan or hyaluronic acid). The extracellular
matrix in most vertebrates express HA, which is a high molecular weight linear polysaccharide composed of alternating
glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds. The three HAS genes show
distinct patterns of expression during development and their protein products play significantly different roles in the formation
of the HA matrix. Both HAS1 and HAS2 synthesise high molecular-weight HA, whereas HAS3 produces lower molecular
weight HA. The expression of the three HAS isoforms is more prominent in growing cells than in resting cells and is differentially
regulated by various stimuli suggesting distinct functional roles of the three proteins. HAS2 mRNA shows predominant expression
in chondrocytes and cartilage. The human HAS2 gene maps to chromosome 8q24.12.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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