货品编号： 博奥森.bs-13334R

品牌： 博奥森

品名： Rabbit Anti-GEN1 antibody

规格： 100ul/支

Endonuclease which cleaves flap structures at the junction between single-stranded DNA and double-stranded DNA.

Specific for 5'-overhanging flap structures in which the 5'-upstream of the flap is completely double-stranded. Prefers

the blocked-flap structures similar to those occurring at replication forks, in which the 5' single-strand overhang of the

flap is double-stranded.

Function:

Endonuclease which resolves Holliday junctions by the introduction of symmetrically related cuts across the junction point,

to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as

Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper

chromosome segregation.