货品编号： bioss.bs-1092R

品牌： bioss

品名： Rabbit Anti-MRP2/ABCC2 antibody

规格： 50ul

multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC

proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct

subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is

involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in

biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug

resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson

syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC

transporter family.