货品编号： bioss.bs-1092R
品牌： bioss
品名： Rabbit Anti-MRP2/ABCC2 antibody
规格： 50ul
multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is
involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in
biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug
resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson
syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC
transporter family.
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