货品编号： bioss.bs-1024R

品牌： bioss

品名： Rabbit Anti-GDNF antibody

规格： 50ul

Neurobiology. Neurotrophins. Neuroscience.

This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote

the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons

induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The

mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In

addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as

astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung

disease.