货品编号： Bioss.bs-2770R

品牌： Bioss

品名： Rabbit Anti-Gab1 antibody

规格： 50ul

产品编号bs-2770R英文名称Gab1中文名称接头蛋白Gab 1抗体别名GRB 2 associated binder 1; GRB 2 associated binding protein 1; GRB2 associated binding protein 1 isoform a; GRB2 associated binding protein 1 isoform bl; Gab 1; Gab1; GAB1_HUMAN; GRB2 associated binder 1; GRB2 associated binding protein 1 isoform b; GRB2-associated binder 1; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1.研究领域肿瘤细胞生物信号转导细胞凋亡细胞周期蛋白激酶和磷酸酶细胞膜受体细胞分化抗体来源Rabbit克隆类型Polyclonal交叉反应(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)产品应用WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.分子量76kDa细胞定位细胞浆性状Liquid浓度1mg/ml免疫原KLH conjugated synthetic peptide derived from human Gab1:601-694/694亚型IgG纯化方法affinity purified by Protein A储存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed产品介绍Growth factor triggering of protein tyrosine kinase receptors induces signals that cascade to the nucleus, activating mitogenic as well as other responses. Critical components of this process include adapter proteins such as Shc, IRS-1 and Gab 1 (GRB-associated binder-1) that lack detectable catalytic activity (1-3,8). Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c Met), and epidermal growth factor receptor (EGF), as well as in response to cell cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3 kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.Function:Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR).Subunit:Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.Similarity:Belongs to the GAB family.Contains 1 PH domain.SWISS:Q13480Gene ID:2549Database links:

Entrez Gene: 2549Human

Entrez Gene: 14388Mouse

Entrez Gene: 361388Rat

Omim: 604439Human

SwissProt: Q13480Human

SwissProt: Q9QYY0Mouse

Unigene: 618456Human

Unigene: 80720Human

Unigene: 277409Mouse

Unigene: 1725Rat

Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.Gab1作为一种分布广泛的接头蛋白，几乎能连接所有类型的受体（如酪氨酸激酶受体、G-蛋白偶联受体、细胞因子与抗原受体等，Gab1蛋白属于接头蛋白Gab家族,该家族蛋白因能与生长因子受体结合蛋白2（Grb2）相结合而得名。作为接头蛋白,Gab1蛋白能被多种受体酪氨酸激酶或非受体酪氨酸激酶激活,接受胞外多种生长因子、细胞因子和一些T/B细胞抗原受体的刺激,介导PI3K/Akt和Ras/MAPK等多条信号转导途径,具有促进细胞生长、迁移、调节免疫等多种生物学功能,与糖尿病、肿瘤、心血管疾病等的发生发展密切相关。