货品编号： Bioss.bs-14498R

品牌： Bioss

品名： Rabbit Anti-EDARADD antibody

规格： 50ul

产品编号bs-14498R英文名称EDARADD中文名称少汗型外胚层发育不良相关蛋白EDAD抗体别名Cr; Crinkled homolog; ectodysplasia A receptor associated death domain; Ectodysplasin-A receptor-associated adapter protein; ED3; EDA3; EDAD_HUMAN; EDAR associated death domain; EDAR-associated death domain protein; EDARADD; Protein crinkled homolog.研究领域发育生物学信号转导表观遗传学抗体来源Rabbit克隆类型Polyclonal交叉反应Mouse, (predicted: Human,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)产品应用WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复）

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.分子量25kDa细胞定位细胞浆性状Liquid浓度1mg/ml免疫原KLH conjugated synthetic peptide derived from human EDARADD:1-100/215亚型IgG纯化方法affinity purified by Protein A储存液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.PubMedPubMed产品介绍This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands. The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives. This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth. Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]Function:Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B.Subcellular Location:Cytoplasm.Tissue Specificity:Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis.DISEASE:Defects in EDARADD are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.Similarity:Contains 1 death domain.SWISS:Q8WWZ3Gene ID:128178Database links:

Entrez Gene: 128178Human

Entrez Gene: 171211Mouse

Entrez Gene: 498769Rat

Omim: 606603Human

SwissProt: Q8WWZ3Human

SwissProt: Q8VHX2Mouse

Unigene: 352224Human

Unigene: 159671Mouse

Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.产品图片Paraformaldehyde-fixed, paraffin embedded (mouse pancreas); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (EDARADD) Polyclonal Antibody, Unconjugated (bs-14498R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.