产品英文名称：TGF-β1,human

产品中文名称：人TGF-β1蛋白

TGF-β1产品介绍：

TGF-β1是一组蛋白超家族。TGF-β1是由两个结构相同或相似，分子量为12.5kD的亚单位通过二硫键连接而成的双体。在人的心肌成纤维细胞、血管内皮细胞和巨噬细胞等均有表达。TGF-β1信号通路的关键传导分子为胞质蛋白Smads,他们可以将TGF-β1信号直接由细胞膜受体传导人细胞核内，是受体激酶介导的细胞内信号传导的新途径，为细胞信号跨膜后与核内基因转录之间开通了一条简便路径。不同的Smad介导不同的TGF-β1家族成员的信号转导。TGF-β1／Smad信号转导通路活化后，可以促进相关基因的转录，如胶原蛋白的表达增高，也可通过调节MMPs／TIMPs表达的平衡抑制胶原降解，促进组织纤维化。

TGF-β1产品特性：

» TGF-β1活性经过人源细胞鉴定，纯度高。

» 生物活性在人源293细胞经过SMAD实验鉴定The EC50为 0.1–1.0 ng/ml。

» TGF-β1产品经过SDS-PAGE 和HPLC双层鉴定纯度大于95%。

TGF-β1产品英文简述：

Members of TGF-family are multifunctional cytokines that regulate cell proliferation, growth, differentiation and migration as well as synthesis of the extracellular matrix. The three human isoforms, TGF- 1, 2, 3, signal through the same receptor and elicit similar biological responses. The release of biologically active TGF-isoform from a latent complex involves proteolytic processing of the complex. TGF-1 is the most abundant isoform secreted by almost all cell types. Human TGF-1 is a 25.0kDa protein with each subunit containing 112 amino acid residues, linked by a disulfide bond.

• Purity: Greater than 95% as determined by SDS-PAGE and HPLC analyses

• Biological Activity: The activity was determined by using a SMAD reporter gene assay in human 293 cells. The EC50 ranges from 0.1 – 1.0 ng/ml.

• For Research Use Only. Not for Use in Humans.