产品英文名称：R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A

产品中文名称：R&D 338-AC-050重组人/小鼠/大鼠激活素A

R&D 338-AC-010 Recombinant Human/Mouse/Rat Activin A 产品研究背景

Activin and Inhibin are members of the TGFβ superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis. Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfidelinked dimers of the bioactive proteins .Activins are nonglycosylated homodimers or heterodimers of various β subunits (βA, βB, βC, and βE in mammals), while Inhibins are heterodimers of a unique α subunit and one of the β subunits. R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A is a widely expressed homodimer of two βA chains. The βA subunit can also heterodimerize with a βB or βC subunit to form Activin AB and Activin AC, respectively. The 14 kDa mature human βA chain shares 100% amino acid sequence identity with bovine, feline, mouse,porcine, and rat βA. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK4. Signaling through this receptor complex leads to Smad activation and regulation of activinresponsive gene transcription. The bioactivity of R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A is regulated by a variety of mechanisms. BAMBI, Betaglycan, and Cripto are cellassociated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly .The intracellular formation of R&D 338-AC-010 Recombinant Human/Mouse/Rat Activin A can be prevented by the incorporation of the βA subunit into Activin AC or Inhibin A. And the bioavailability of R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A is restricted by its incorporation into inactive complexes with α2Macroglobulin,Follistatin, and FLRG .

R&D 338-AC-050重组人/小鼠/大鼠激活素A产品简介

激活素和抑制素是细胞因子TGF-β超家族的成员，参与广泛的生物学过程，包括组织形态发生和修复，纤维化，炎症，神经系统的发育，造血，生殖系统的功能，和癌变。R&D 338-AC-050 重组人/小鼠/大鼠激活素A是一种广泛表达的同源二聚体的两个βA链。 βA亚基也可以在异源与βB或βC亚基形成AB激活素和激活素AC 。R&D 338-AC-050 重组人/小鼠/大鼠激活素A的生物活性受多种机制调节 。 激活素细胞内形成A被βA亚基激活素AC或抑制素A 阻碍 。

激活素最初从性腺流体纯化蛋白质，刺激垂体促卵泡刺激素（FSH）释放的二硫键连接的二聚体蛋白。激活素蛋白具有广泛的生物活性，包括中胚层诱导，神经细胞的分化，骨重塑，造血和生殖生理学的角色。激活素的异构体和转化生长因子- β超家族的其他成员的结合的异源复合物的类型I和II型的丝氨酸 - 苏氨酸激酶受体，这两者都是必不可少的信号转导中发挥其生物效应。

激活素的各种β亚基异构体的同二聚体或异二聚体，而抑制素是一个独特的α亚基和的各种β亚基之一的异源二聚体。五β亚基（哺乳动物beta A, beta B, beta C, beta E and Xenopus beta D)至今已被克隆。激活素/抑制素的命名反映的蛋白质亚基组成：激活素A (beta A - beta A) ，激活素B(beta B - beta B)， AB激活素(beta A - beta B) ，抑制素(alpha - beta A)及抑制素B(alpha - beta B) 。

R&D 338-AC-050 Recombinant Human/Mouse/Rat Activin A 保存方法

Use a manual defrost freezer and avoid repeated freezethawcycles.

»12 months from date of receipt, -20to -70°C as supplied.

»1 month, 2 to 8 °C under sterile conditions after reconstitution.

»3 months, -20to -70°C under sterile conditions after reconstitution.

R&D 338-AC-050重组人/小鼠/大鼠激活素A系列产品订购信息

R&D Recombinant Human/Mouse/Rat Activin A 338-AC-01M 1 mg

R&D Recombinant Human/Mouse/Rat Activin A 338-AC-010 10 µg

R&D Recombinant Human/Mouse/Rat Activin A 338-AC-050 50 µg

For Research Use Only. Not for Use in Humans.