产品英文名称：Dkk-1 Fc fusion, human,DKKFC-050,50ug

产品中文名称：人源Dkk-1蛋白Fc融合WNT信号通路抑制剂

Dkk-1 Fc fusion, human,DKKFC-050,50ug 产品简介

DKK-1是重组人Dickkopf相关蛋白1的简称，是DKK蛋白干细胞生长分化调整因子家族（DKK1-4）的一员。DKK蛋白干细胞生长分化调整因子最初被认为是非洲爪蟾蜍的前期成形细胞。通过机理 研究发现DKK-1通过与共同受体LRP5/6一起形成抑制复合物，可以有效抑制Wnt/β-catenin信号通路。研究人员发现敲除DKK-1基因小 鼠的脑部无法形成，从而证实Wnt/β-catenin信号通路的抑制在脊椎动物的后模式与前模式发展中必不可少。

当DKK-1融于人IgG1蛋白的Fc片段时，这种融合避免了蛋白在体内体外环境下的显著失活，有效保证了其稳定性。

人源Dkk-1蛋白Fc融合WNT信号通路抑制剂,50ug 产品特性

»人源Dkk-1蛋白干细胞生长分化调整因子Fc融合WNT信号通路抑制剂,50ug鉴定纯度大于90%

»人源Dkk-1蛋白干细胞生长分化调整因子Fc融合WNT信号通路抑制剂,50ug生物活性在培养人细胞中用TCF受体基因检测确定，拮抗剂WNT-3a 100 ng/mL时其IC50在200 - 1000 ng/ml之间

Dkk-1 Fc fusion, human,DKKFC-050,50ug 保存方法

The lyophilized protein is stable for at least one year if stored at -80 degreeC. Reconstituted protein is stable for at least four weeks at 4 degree C, but should be stored in aliquots at -80 degree C for longer term. Avoid repeated freeze and thaw.

Dkk-1 Fc fusion, human,DKKFC-050,50ug 产品英文描述

DKK-1, Dickkopf-related protein-1, is a member of the DKK protein family which includes DKK-1 through DDK-4. DKK was originally identified as a head-forming molecule in Xenopus. Mechanistic studies showed that DKK-1 inhibits the Wnt /β-catenin signaling pathway by forming inhibitory complexes with co-receptor LRP5/6. Inhibition of Wnt/β-catenin signaling is essential for posterior patterning and anterior development in vertebrates, supported by the discovery that DKK-1 knockout mice lack head formation. When DKK-1 is fused to the Fc fragment of human IgG1. This fusion renders stability of the protein in vitro and in vivo without significant loss of activity.

StemRD expresses Dkk-1 Fc fusion, human,DKKFC-050,50ug in human 293 cells and purifies it by protein A column.

• Dkk-1 Fc fusion, human,DKKFC-050,50ug Purity Greater than 90% as determined by SDS-PAGE analysis

• Dkk-1 Fc fusion, human,DKKFC-050,50ug Biological Activity The activity was determined by using a TCF reporter gene assay in cultured human cells. The IC50 ranges from 200 - 1000 ng/ml in the inhibition of 100 ng/mL WNT-3a activity. Activity in other assays should be determined by each individual setting.

人源Dkk-1蛋白Fc融合WNT信号通路抑制剂系列产品订购信息

StemRD DKK-025 25ug 优惠价格请来电咨询

StemRD DKK-100 100ug 优惠价格请来电咨询

StemRD DKK-500 500ug 优惠价格请来电咨询

StemRD DKKFC-050 50ug 优惠价格请来电咨询

StemRD DKKFC-250 250ug 优惠价格请来电咨询

StemRD DKKFC-1000 1000ug 优惠价格请来电咨询

For research use only. Not intended for human or animal diagnostic or therapeutic uses.