货品编号：SignalChem.E10-12DG-10

品牌：SignalChem

品名：EGFR Mutant (T790M L858R), Active

规格：10UG

保存：–70°C.

Description: Recombinant human EGFR (T790M L858R) (695-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Tag:GST tag

Expression System:Sf9 insect cells using baculovirus

Species:Human

Sequence:695-end (T790M L858R)

Genbank Number:NM_005228

Storage, Stability and Shipping: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications: Kinase Assay

Molecular Weight: ~89 kDa

Gene Aliases: ERBB, mENA, ERBB1, HER1

Scientific Background: EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. Binding of epidermal growth factor to EGFR induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation, differentiation, motility, and cell survival. Activation of EGFR triggers mitogenic signaling in gastrointestinal mucosa, and its expression is upregulated in colon cancers and most neoplasms. Activation of EGFR triggers activation of the ERK-signaling pathway in normal gastric epithelial and colon cancer cell lines. Inactivation of EGFR with selective inhibitors significantly reduces ERK2 activation, c-fos mRNA expression and cell proliferation.