品牌：Peprotech

规格：2 µg

别名:

Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

描述:

M-CSF is a potent hematopoietic factor produced by a variety of cells, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their respective progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness and fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant Rat M-CSF is a 36.2 kDa homodimeric protein consisting of two 155 amino acid polypeptide subunits.

氨基酸序列:

MEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ

EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL

QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF

FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP

来源: E.coli

纯度: Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 5.0 ng/ml, corresponding to a specific activity of ≥ 2 x 105 units/mg.

交叉反应: Mouse, Rat

研究领域：