货品编号： Peprotech.100-36E-10

品牌： Peprotech

品名： Human TGF-beta3 (E.coli)

规格： 10ug

产品描述

The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses.

They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition

of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound

healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix.

The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction

of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown, but its expression

pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-β3 is a 25.0 kDa protein composed

of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.