货品编号: Peprotech.400-30-50
品牌: Peprotech
品名: Recombinant Rat sRANK Ligand
规格: 50ug
产品描述
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of
specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by
interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a
mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL,
which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also
capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by
interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone
and cartilage. Recombinant Rat sRANKL is a 19.4 kDa polypeptide comprising the TNF homologous region of RANKL (174 amino
acid residues).
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