货品编号： Sigma.T5201

品牌：Sigma

品名： Monoclonal Anti-β-Tubulin antibody produced in mouse

规格： 200UL

Immunogen tubulin from rat brain.

Specificity The antibody recognizes all five isoforms of β-tubulin (β1-β5). It reacts with the β-Lc and β-Sc fragments in the carboxy-terminal part of

β−tubulin in immunoblotting. The antibody may be used to localize β−tubulin in cultured cells or tissue sections.

Physical form Solution in 0.01 M phosphate buffered saline containing 15 mM sodium azide.

Application Monoclonal Anti-β-Tubulin antibody produced in mouse has been used in western blotting.[1]

Biochem/physiol Actions Mutation in the gene leads to various neuronal migration disorders such as lissencephaly, pachygyria and polymicrogyria malformations.[3]

B2702 peptide binds to β-tubulin and inhibits NK cell cytotoxicity and it influences microtubule polymerization, which damages cytoskeleton

organization and chaperone-like activity of tubulin.[5] β-1 tubulin also known as class VI or TUBB1, plays a vital role in platelet production,

and is considered to be a potential biomarker candidate for immune thrombocytopenia (ITP).[7]

General description β-Tubulin belongs to the subfamily of tubulin, which is the major building block of microtubules. β-Tubulin has a molecular weight of 55kDa.[8][2]

β-Tubulin structure is characterized with core of two β-sheets enclosed by α-helices. It also contains an N-terminal domain with the guanine

nucleotide-binding region, an intermediate domain with taxol-binding site, and a C-terminal domain that contains the binding surface for molecular

motor proteins.[4] Human β-tubulin consists of seven isoforms (βI (class I), βI (class II), βIII (class III), βIVa (class IVa), βIVb (class IVb), βV (class V),