货品编号： Sigma.P4394-100mg

品牌： Sigma

品名： 顺铂

规格： 100mg

产品描述

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the

immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased

cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and

Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.