货品编号： Sigma.P8139-1mg 品牌： Sigma 品名： Phorbol 12-myristate 13-acetate 规格： 1mg

Biochem/physiol Actions Potent tumor promoter; activates protein kinase C in vivo and in vitro.

Caution Photosensitive

Application Phorbol 12-myristate 13-acetate has been used for the stimulation of various cells including spleen cells, quiescent

lymphocytes and fetal thymocytes.[2][3][4] It has also been used for the activation of PKC (protein kinase C) in cells.[5]

Features and Benefits This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a

biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To

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General description Phorbol 12-myristate 13-acetate is a phorbol ester. It works as a tumor promoter and is involved in gene transcription, cell

growth, differentiation, programmed cell death, immune pathway and receptor desensitization via protein kinase C (PKC)

signaling pathways. Phorbol 12-myristate 13-acetate is also a model agent to study growth factors-, hormones-, and

cytokines-mediated regulation of cellular growth and differentiation.[1]