货品编号： Signalchem.G09-14G-20 品牌： Signalchem 品名： GSK3 beta, Unactive 规格： 20 ug

Description: Recombinant full-length human GSK3beta was expressed in E. coli cells using an N-terminal GST tag.

Species: Human

Tag: GST tag

Expression System: E.coli

Sequence: Full Length

Genbank Number: NM_002093

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after

centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and

multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~75 kDa

Scientific Background : GSK3β is a serine threonine protein kinase that was originally identified as the kinase that phosphorylate

and inhibits glycogen synthase (1). GSK3β is ubiquitously present in human tissues and implicated in the regulation of several

physiological processes, including the control of glycogen and protein synthesis by insulin, modulation of the transcription factors

AP-1 and CREB. Transient transfection of human GSK3 beta into Chinese hamster ovary cells stably transfected with individual

human tau isoforms leads to hyperphosphorylation of tau at all the sites investigated with phosphorylation-dependent anti-tau antibodies (2).