货品编号： Signalchem.P05-30G-20 品牌： Signalchem 品名： CELL CYCLE PROTEINS - p53 Protein 规格： 20 ug

产品描述：

Description: Recombinant full-length human p53 was expressed in E. coli cells using an N-terminal GST tag. Species: Human Tag: GST tag Expression System: E.coli Sequence: Full Length Genbank Number: NM_000546 Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities

after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling

and multiple freeze/thaw cycles.

Applications : Kinase Assay, Western Blot

Molecular Weight : ~79 kDa

Gene Aliases : TP53, LFS1, TRP53

Scientific Background : p53 is a key regulator of cell growth and acts as a tumor suppressor gene. Wild-type p53 gene

can suppress transformation of rat embryo fibroblasts in cell culture by other oncogenes such as the adenovirus E1A and

Ras (1). DNA tumor viruses such as SV40 large T antigen and the adenovirus E1A plus E1B-55Kd proteins bind to p53

and inactivate its tumor suppressor activities leading to cellular transformation. Mutational inactivation of the p53 gene is

detected in more than 50% of human cancers. Mutation of p53 renders cancer cells more resistant to current cancer therapies

due to lack of p53-mediated apoptosis (2).