货品编号： Bioss.bs-1353R 品牌： Bioss 品名： Rabbit Anti-Beclin 1 antibody (bs-1353R) 规格： 50ul

产品描述：

background: Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function.

Autophagy, a process of bulk protein degradation through an autophagosomic lysosomal pathway, is important for

differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1

was originally isolated in a yeast two hybrid screen to identify Bcl 2 binding partners and maps to a tumor susceptibility locus

on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin

1 encodes an evolutionarily conserved 52kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons.

Function: Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense.

Protects against infection by a neurovirulent strain of Sindbis virus.

Subunit: Interacts with GOPC and GRID2. Interacts with AMBRA1. Forms a complex with PIK3C3 and PIK3R4 and either UVRAG and

KIAA0226/Rubicon, or with ATG14. UVRAG and ATG14 form mutually exclusive complexes through direct competition for

BECN1-binding. The complex containing ATG14 up-regulates autophagy, while the one containing Rubicon down-regulates

autophagy. Interacts with BCL2 and BCL2L1. Interacts with VMP1. Interacts with PIK3CB. Interacts with DAPK1. Interacts with

human cytomegalovirus/HHV-5 protein TRS1.

Subcellular Location: Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Note=Interaction with ATG14 promotes translocation

to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.

Tissue Specificity: Ubiquitous.

Post-translational modifications: Phosphorylation at Thr-119 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy. Ubiquitinated. Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes.

Similarity: Belongs to the