货品编号： Bioss.bs-7727R

品牌： Bioss

品名： Rabbit Anti-SMC2 antibody

规格：100ul

产品描述：

background: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like

condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence

of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Function: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like

condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence

of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Subunit: Forms a heterodimer with SMC4. Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer,

and three non SMC subunits that probably regulate the complex: BRRN1/CAPH, CNAP1/CAPD2 and CAPG.

Subcellular Location: Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm,

while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with

chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset

of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome

arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Similarity: Belongs to the SMC family. SMC2 subfamily.

SWISS: O95347

Gene ID: 10592

Database links: UniProtKB/Swiss-Prot: O95347.2

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.