货品编号： Sigma.S0130

品牌： Sigma

品名： 链脲佐菌素（STZ）

规格：500mg

产品描述：

Application Streptozocin or streptozotocin is used to induce type 1 diabetes for medical research.[3][4][5]

Biochem/physiol Actions An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells,

producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to

neuroendocrine tumor cell lines that express the GLUT2 glucose transporter. Clinically, the chemical is used for the treatment of pancreatic β cell carcinoma.[2]

Features and Benefits This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug

Candidates, click here.

General description Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes.[1] Streptozotocin, a glucosamine-nitrosourea, is a

DNA alkylating agent that enters cells exclusively via the GLUT2 glucose transport protein. Streptozocin, a diabetagen, is especially

toxic to pancreatic islet insulin-producing β-cells. It is toxic to GLUT2 positive neuroendocrine tumor cells.