货品编号： Invitrogen.45-0261-82 品牌： Invitrogen 品名： Anti-Mouse CD26 PerCP-Cyanine5.5 规格：100ug

产品描述

Description: The monoclonal antibody H194-112 recognizes mouse CD26, a thymocyte-activating molecule (THAM). CD26 is a surface

expressed and soluble ectoenzyme (dipeptidyl peptidase IV) that cleaves dipeptides from the amino terminus of proteins. In particular

CD26 has been shown to cleave CXCL12, CCL22, neuropeptide Y and glucagon. CD26 is involved in adhesion, apoptosis, disease

regulation, and engraftment. Expression is regulated during thymic development at the messenger RNA level. Additionally, CD26 protein

is found on thymocytes, a percentage of resting B cells, stimulated B cells, NK cells and a percentage of resting and activated T cells and

other epithelial cell types. On human cells more CD26 protein is found on Th2 cells. Functional CD26 is expressed on Sca-1+c-Kit+lin- cells.

This expression has been shown to correlate with mobilization of progenitor cells. Inhibition of CD26 activity through a variety of compounds

enhances allogenic stem cell homing and engraftment.

This antibody is reported to have activating function.

Applications Reported: This H194-112 (H194-112.12.4.4.5) antibody has been reported for use in flow cytometric analysis.

Applications Tested: This H194-112 (H194-112.12.4.4.5) antibody has been tested by flow cytometric analysis of mouse splenocytes or

thymocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell

sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is

recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 695 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.