货品编号： Bioss.bs-10589R

品牌： Bioss

品名：Rabbit Anti-Collagen II antibody

规格：200ul

产品描述：

background: Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat

that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies

with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three

dimensional epitopes. This may result in diminished reactivity of some antibodies with denatured collagen or formalin fixed,

paraffin embedded tissues. Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye.

Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of

cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early

onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I,

and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding

protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts

identified for this gene.