货品编号： Sigma.L1381

品牌：Sigma

品名：L-α-溶血卵磷脂 来源于牛大脑

规格：5mg

产品描述：

Biochem/physiol Actions Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory

reactions, including atherosclerosis. It is a degradation product of phosphatidylcholine by phospholipase A and has cytolytic properties.

The product is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C,

p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine

accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic

damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels.

Features and Benefits This compound is featured on the Phospholipase D page of the Handbook of Receptor Classification and Signal Transduction. To browse

other handbook pages, click here.