产品描述：

Function: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP

response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic

transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-

induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-

responsive C3 promoter region.

Subunit:

Homodimer. Interacts with CREB1; the interaction is not depolarization dependent. Interacts with CREBBP (via C-terminus)

(By similarity). Interacts (via HGM box) with CITED1 (via C-terminus); the interaction increases estrogen-response

element (ERE)-dependent transcription and protection against cell death. Interacts with CREB1 (phosphorylated form).

Subcellular Location: Nucleus (Probable).

Tissue Specificity: Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in

the frontal and occipital lobe.