货品编号： bioss.bs-20067R 品牌：bioss 品名：Rabbit Anti-C-jun antibody 规格：100ul 产品描述： background: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA

lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded

protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease

catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in

recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in

cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis.

Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with

the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]