货品编号： 博奥森.bs-3863R 品牌：博奥森 品名：ROR Gamma孤儿核受体抗体 规格：50ul 产品描述：

background: The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of

nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene

in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory

role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the

expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.

[provided by RefSeq, Jul 2008].

Function: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment.

Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved

in lineage specification of uncommitted CD4(+) T helper cells into Th17 cells. Regulate the expression of several

components of the circadian clock.