货品编号： 博奥森.bs-3397R 品牌：博奥森 品名：Rabbit Anti-Phospho-SGK1 (Thr256) antibody 规格： 100ul 产品描述：

background: SGK1 is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium,

sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival,

neuronal excitability, and renal sodium excretion. Sustained high levels of SGK1 and activity may contribute to

conditions such as hypertension and diabetic nephropathy. This protein also mediates cell survival signals, as it has

been shown to phosphorylate and negatively regulate the pro apoptotic FOXO3A protein. Ser 422 is a critical site on

the protein and may be involved in its activation.

Function: Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride

channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal

sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic

nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates

NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC,

KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+)

transport than isoform 1.