货品编号： Bioss.bs-14659R 品牌：Bioss 品名：Rabbit Anti-EXOC2 antibody 规格：100ul 产品描述：

background: ExoC3L is a 746 amino acid protein that belongs to the SEC6 family. Localizing to the cytoplasmic and secretory vesicle,

ExoC3L colocalizes with insulin granules and interacts with ExoC2, ExoC4 and ExoC5. Acting as part of the exocyst, ExoC3L

may function in the regulation of insulin granule exocytosis and is expressed in insulin-secreting MIN6 cells, as well as various

tissues including brain and pancreatic islets. The gene encoding ExoC3L maps to human chromosome 16, which encodes over

900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation,

may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare

disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal

inflammatory condition.

Function: As part of the exocyst, may play a role in regulated exocytosis of insulin granules.