货品编号： Sigma.P9582-5MG 品牌：Sigma 品名：Polyinosinic–polycytidylic acid potassium salt with buffer salts, TLR ligand tested 规格：5MG
产品描述： Biochem/physiol Actions Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell
apoptosis. Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB,
p50/p65 nuclear translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of
caspase 12, Fas, IL-15, and the TNF receptor-associated ligand (TRAIL). It has been suggested that
Poly(I:C) is one of the most appropriate generators of stable mature dendritic cells (DC). These mature DC
might generate in vivo effective immune responses after injection due to their ability to secrete bioactive IL-12
after CD40 ligation. Poly (I:C) was used as a potent adjuvant to enhance the specific anti-tumor immune
responses against a peptide-based vaccine.
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