货品编号： Thermo.MA5-12960 品牌：Thermo 品名：Cardiac Troponin T Monoclonal Antibody (13-11) 规格：500ul

产品描述： Product Specific Information MA5-12960 targets Troponin T Cardiac Isoform in IF/ICC, IHC (P), and IM applications and shows reactivity with Avian,

Canine, Chicken, Fish, Guinea Pig, Human, mouse, Porcine, Rabbit, and Rat samples.

The MA5-12960 immunogen is purified rabbit cardiac troponin T isoform (TnT4R).

Background/Target Information Cardiac Troponin T is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of

striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration.

Cardiac Troponin T is important in proper muscle function and myofibril formation. In the human heart, four cTnT isoforms

are expressed in a developmentally regulated manner. Cardiac Troponin T expression in the human heart is affected by

heart failure. Mutations within the Cardiac Troponin T protein have been associated with familial hypertrophic cardiomyopathy

as well as with dilated cardiomyopathy. Transcripts for the Cardiac Troponin T gene undergo alternative splicing that results

in many tissue-specific isoforms.