博奥森.bsm-33400M Collagen II型胶原单克隆抗体 50ul Bioss


货品编号: 博奥森.bsm-33400M 品牌:博奥森 品名:Collagen II型胶原单克隆抗体 规格:50ul

产品描述: ackground: This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains

and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in

bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types

I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic

osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for

platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called

dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts,

resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by

R. Dalgleish, Feb 2008].

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