货品编号： cayman.16129 品牌： cayman 品名： Chlorpromazine (hydrochloride) 规格： 500mg

产品描述： Chlorpromazine (CPZ) is a typical antipsychotic and an antagonist of dopamine D2, D3, and D4 receptors

(Kis = 0.66, 0.84, and 1.2 nM, respectively) as well as the serotonin (5-HT) receptor subtype 5-HT2A (Ki =

1.8 nM).1,2 It is also an antagonist of histamine H1, α1a-, α2b-, and α2C-adrenergic, and M3 muscarinic

acetylcholine receptors (Kis = 6, 0.28, 27, 46, and 47 nM, respectively).3 CPZ (10 mg/kg per day) increases

latency to find the platform in a repealed acquisition water maze task and decreases vertical activity and

stereotypic movements in the open field test in rats.4 CPZ (0.3, 1, and 3 mg/kg, s.c.) also reduces emesis

induced by cisplatin (Item No. 13119) in dogs.5