货品编号： Thermo.PA5-27369 品牌：Thermo 品名：CBP Polyclonal Antibody 规格：100 uL

产品描述： Background/Target Information This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors.

First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to

play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to

transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts

as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and

non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-

histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS).

Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results

in multiple transcript variants encoding different isoforms.