货品编号： Peprotech.315-20-10

品牌： Peprotech

品名： Murine WNT-3A

规格：10ug

产品描述

Wnt-3a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues.

Expression of Wnt-3a occurs primarily along the dorsal midline across overlapping regions of the Central Nervous System (CNS).

Wnt-3a signaling is essential for various morphogenetic events, including embryonic patterning, cell determination, cell proliferation,

CNS development, and cytoskeletal formation. Like other members of this family, Wnt-3a contains a highly conserved lipid-modified,

cysteine-rich domain that is essential for cell signaling. During a biochemical process called the canonical Wnt pathway, Wnt family

members bind to and activate, seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of

β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to

TCF/LEF transcription factors to promote gene expression. Lack of Wnt signaling disrupts transcriptional activation of tumor suppressor

genes, and has been shown to result in neoplastic transformation, oncogenesis, and human degenerative diseases. Recombinant Murine

Wnt-3a is a monomeric glycoprotein containing 334 amino acid residues. Due to glycosylation, the Murine Wnt-3a migrates at an apparent

molecular weight of approximately 38.0-41.0 kDa by SDS-PAGE analysis under non-reducing conditions.