产品描述： background: KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles

in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008]

Function: Plays an essential role in cytokinesis.

Subunit: Directly interacts with PRC1 within a complex also containing KIF4A, KIF20A and KIF23. Directly interacts with CIT depending

on the activation state of the kinase (stronger interaction with the kinase-dead form). Interacts with ARRB2; the interaction is

detected in the nucleus upon OR1D2 stimulation.

Subcellular Location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Nuclear localization observed during interphase in PubMed:

16431929 or triggered by entry into mitosis in PubMed:16648480. Cytoplasmic in interphase (PubMed:16648480) and metaphase

cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules.

During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent

upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring.