产品描述： background: Piccolo is 1 component of the presynaptic cytomatrix. Bassoon is a large protein which is also found in the presynaptic

compartments of rat brain synapses. Bassoon, along with Piccolo, is part of the ensemble of presynaptic proteins that

are involved in orchestrating events at the nerve terminal. Bassoon is found in axon terminals of hippocampal neurons

where it is highly concentrated in the vicinity of the active zone. Piccolo has a similar distribution and colocalizes with

Bassoon in cultured hippocampal cells. Piccolo zinc fingers interact with the dual prenylated rab3A and VAMP2/ Synaptobrevin

II receptor PRA. Bassoon may be involved in cytomatrix organization at the site of neurotransmitter release. The gene which

encodes bassoon maps to human chromosome 3p21.31. The gene which encodes piccolo maps to human chromosome 7q21.11.

Function: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.

Subunit: Interacts with RABAC1/PRA1, RIMS2 and profilin (By similarity).

Subcellular Location: Cell junction, synapse. Note=Concentrated at the presynaptic side of synaptic junctions.