产品描述： background: Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits.

They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma

membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations

in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

Function: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to

opening of an ion-conducting channel across the plasma membrane.

Subunit: Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3

or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.

Subcellular Location:

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.