货品编号： 博奥森.bs-1739R 品牌：博奥森 品名：信号通路Wnt1抗体 规格：50ul

产品描述： background: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins

have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and

patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution,

and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level.

The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum.

This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with

cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have

a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome

12q13 region.

Function: Ligand for members of the frizzled family of seven transmembrane receptors. In some developmental processes, is also

a ligand for the coreceptor RYK, thus triggering Wnt signaling. Probable developmental protein. May be a signaling molecule

important in CNS development. Is likely to signal over only few cell diameters.

Subunit: Interacts with PORCN. Interacts with RSPO1, RSPO2 and RSPO3 (By similarity). Interacts with WLS (By similarity).

Subcellular Location: Secreted, extracellular space, extracellular matrix.

Post-translational modifications: Palmitoylation at Ser-224 is required for efficient binding to frizzled receptors. It is also required for subsequent palmitoylation

at Cys-93. Palmitoylation is necessary for proper trafficking to cell surface.