产品描述： Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases.

This cell permeable inhibitor targets the multiple isoforms of PP1 (IC50 = 10-50 nM), both isoforms of PP2A

(IC50 = 0.5 nM) and PP3 (IC50 = 4 nM).1,2,3 It is a very weak inhibitor of PP2B (IC50 > 2 μM) and does not

inhibit PP2C or other phosphatases.1,3 Presumably through these actions, okadaic acid is a potent carcinogen

and induces tau phosphorylation.4,5 In sponge, okadaic acid plays a role in defense, inducing apoptosis in

symbiotic or parasitic annelids.