产品描述： background: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins

heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically

dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role

in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in

this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Subunit: Heterotetramer of two type I and two type II keratins. KRT8 associates with KRT18. Associates with KRT20. Interacts with HCV

core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1.

Subcellular Location:

Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix.

Tissue Specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain

dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.